New Strategies to Prevent Canine Posterior Capsule Opacification [after cataract surgery]

Speaker: Heather Chandler, DVM, PhD, The Ohio State University

Health Conference Articles

2013 Health Conference Report
The Genius of Dogs
Canine Epilepsy: Where We Are and Where We are Going
Inherited Cardiomyopathies - Understanding Unique Clinical and Genetics Aspects for Your Breed
New Strategies to Prevent Canine Posterior Capsule Opacification
Investigation of Cranial Cruciate Ligament Deficiency and Associated Surgical Interventions Using Computer Simulation
Application of Physical Therapy Techniques to our Canine Patients:  The Current Science and Research Opportunities
Regenerative Medicine for Soft Tissue Injuries in the Canine
Bloat: What We Know and Where We Are Going 
High-Risk High-Reward Focus Areas for Research in Canine Gastroenterology: A Clinician-Scientists Perspective 
Genetics 101 for Dog Breeders 
Canine Hemangiosarcoma: How Much Do We Really Know and When Will We Find a Cure?  
The Cytogenomic Landscape of Canine Cancer  

Cataracts are a progressive change to the lens of the eye, resulting in cloudiness and interference with vision. Cataracts are the most common cause of blindness in dogs. Surgical removal of the lens, and placement of an intraocular lens implant can restore normal vision. Although every effort is made to remove as much lens material as possible during cataract surgery, it is inevitable that some lens cells remain. These cells will migrate and proliferate, resulting in the most common complication to cataract removal: posterior capsule opacification (PCO), where a new layer of cells on the back of the lens capsule interferes with light transmission and results in secondary vision loss. Cataracts occur in all breeds and PCO occurs in up to 100% of canine post-operative cataract patients. Unfortunately, there is no consistently effective treatment for canine PCO.

The lecture focused on the newer developments of novel therapies to reduce PCO formation including surgical and pharmaceutical interventions. This lecture also discussed potential intraocular [into eye] drug delivery options to prevent PCO. At this time Dr. Chandler is researching whether the drug Cyclosporin A (CsA), can decrease PCO formation and decrease post-operative inflammation. Her goal is to determine whether CsA can provide a safe and reliable option to prevent PCO in dogs.

Learn More about Eyes

  • Cataracts - an article on cataracts provided by the AKC Canine Health Foundation
  • Eye Anatomy - YouTube video on the anatomy and function of the eye

Dr. Chandler’s research primarily focuses on cataract formation and complications associated with them. She has been faculty in the College of Optometry and adjunct faculty in the College of Veterinary Medicine since 2007.



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